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  • JCI - Welcome
    In this issue of the JCI, Spencer et al used a TNF-driven mouse model of small intestinal Crohn’s disease to identify a specific bacterial pathobiont, Chlamydia muridarum, as a necessary and sufficient driver of region-restricted inflammation
  • JCI - About the Journal of Clinical Investigation
    Email staff@the-jci org or call 734-222-6050 To avoid confusion regarding correspondence, inquiries, and decisions, the JCI will typically communicate only with the responsible party corresponding author of submissions
  • JCI - The science of safety: adverse effects of GLP-1 receptor agonists . . .
    The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications
  • JCI - Welcome
    Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)
  • JCI - Author Information Center
    If the JCI Insight editor sends the manuscript for peer review, reviewers will be asked to comment specifically on the suitability and specify revisions required for publication in JCI Insight Decision letters will include comments from both the JCI and JCI Insight editors For further information, visit the Dual-Journal Submission page
  • JCI - Antiinflammatory actions of glucagon-like peptide-1–based . . .
    Therapies based on glucagon-like peptide-1 (GLP-1) reduce rates of cardiovascular and chronic kidney disease in people with type 2 diabetes and or obesity, with ongoing clinical trials investigating their effects in people with metabolic liver disease, arthritis, and both substance use and neurodegenerative disorders Acute and chronic activation of GLP-1 receptor signaling also reduces
  • JCI - Submission instructions - first
    Submit a manuscript directly to the JCI through your account on the JCI’s submission website Follow the instructions to either register for an account or access your existing account Click the button below to open the submission site Submit a manuscript to the JCI and JCI Insight simultaneously using the Dual-Journal Submission option
  • JCI - Allergen-specific mRNA–lipid nanoparticle therapy for prevention . . .
    Allergic diseases have reached epidemic proportions globally, calling attention to the need for better treatment and preventive approaches Herein, we developed allergen-encoding messenger RNA (mRNA)–lipid nanoparticle (LNP) strategies for both therapy and prevention of allergic responses Immunization with allergen-encoded mRNA-LNPs modulated T cell differentiation, inhibiting the
  • JCI - Welcome
    Liver invasion is one of the most frequent events in the progression of gallbladder cancer (GBC) However, the cellular and pathological role of the tumor-liver–interface microenvironment in liver invasion is still enigmatic Here, we applied single-cell and spatial transcriptomics to systematically investigate the cellular component and gene expression regulation of the microenvironment
  • JCI - Regulation of TTN as a mechanism of and treatment for heart failure
    Truncation variants in the gene TTN encoding titin are the most common cause of familial dilated cardiomyopathy (DCM), with both haploinsufficiency and “poison peptide” implicated as contributory mechanisms of disease In this issue of the JCI, Kim et al identify a highly conserved enhancer element approximately 500 bp downstream of the transcriptional start site of TTN in intron 1, which





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