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  • Common structure of soluble amyloid oligomers implies common . . . - ALZFORUM
    Whatever the effects of low n-oligomers, the observation that toxicity mediated by ADDLs and or protofibrils can be ameliorated by anti-oligo suggests that their common structure may mediate toxicity by a common mechanism, and it offers a unique target for therapeutic intervention
  • Sabirnetug - ALZFORUM
    ACU193 blocked oligomers from interacting with cultured hippocampal neurons at an IC50 of 17 nM, and was unaffected by addition of excess Aβ monomer In Tg-AD mice, ACU193 bound soluble oligomers in brain tissue, lessened plaque deposition, and was claimed to reduce abnormal nighttime hyperactivity
  • CAPturing Oligomers from Biofluids | ALZFORUM
    It’s easy to blame soluble oligomers for whatever ails neurons, but it’s hard to isolate and characterize them Now, scientists report a way to capture these nefarious species from biological fluids As described in the July 7 Nature Chemistry, the method relies on a dual-affinity probe called
  • Two Classes of Aβ Oligomers Act Differently in the Brain
    They distinguish between two broad classes of Aβ oligomers, reporting that type 1 and type 2 have distinct structures and behaviors In mouse models, type 1 oligomers appear early, disperse widely through brain tissue, and correlate with subtle cognitive deficits
  • Amyloid-β oligomers drive amyloid deposit and cascaded tau pathology of . . .
    He Z, Zhang W, Chen P, Li S, Tao M, Yue F, Hong W, Feng S, Jing N Amyloid-β oligomers drive amyloid deposit and cascaded tau pathology of Alzheimer's disease in aged brains of non-human primates
  • Aβ Oligomers—Small Steps in Detection, Characterization
    A way to quantify Aβ oligomers in the living brain is widely regarded as a key research priority An oligomer-specific imaging agent might help identify individuals at early stages of AD, provide a pathological correlate of cognitive decline independent of amyloid fibrils, and offer a readout on therapeutic effects To date, the only means of reliably measuring oligomers is by using oligomer
  • Aβ Oligomers: A Fatal Attraction for Glutamate Receptors?
    Despite the risk of getting burned, moths cannot resist a flame Do some glutamate receptors find amyloid-β (Aβ) just as dangerously attractive? Clustering around synthetic Aβ oligomers embedded in the cell membrane, metabotropic glutamate receptors unleash an influx of calcium that is toxic to
  • Cellular prion protein mediates impairment of synaptic . . . - ALZFORUM
    Lauren et al report that Aβ oligomers bind to PrPc and that the detrimental effect of Aβ on hippocampal LTP is not observed in PrPc knockout mice; PrPc presumably mediates this detrimental effect not by direct modulation of glutamate receptors but in an indirect way There are earlier studies hinting at an association of Aβ with PrPc (e g , Brown, 2000; Schwarze-Eicker et al , 2005) but
  • Triple Trouble: New Knock-in Turbocharges Tauopathy
    They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding aggregates Such “seeds” are a hallmark of human tauopathies Recognizing the need for models with more robust pathology at a younger age, the authors engineered the new triple-knock-ins





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