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  • Original Research - ScienceDirect
    In this study, our findings delineate that overexpression of SIRT1 fortifies the intestinal epithelial barrier against DSS, substantially mitigating DSS-induced colitis in mice We further demonstrate that SIRT1 maintains the junctional integrity of intestinal epithelial cells
  • ORIGINAL RESEARCH article
    Taken together, our study indicates that cold exposure may aggravate endoplasmic reticulum stress and damage epithelial tight junctions in the colon by inhibiting SIRT1, which promotes nuclear localization of Nrf2 and induces an anti-oxidant response to maintain intestinal homeostasis
  • SIRT1 Stabilizes β-TrCP1 to Inhibit Snail1 Expression in Maintaining . . .
    In this study, our findings delineate that overexpression of SIRT1 fortifies the intestinal epithelial barrier against DSS, substantially mitigating DSS-induced colitis in mice We further demonstrate that SIRT1 maintains the junctional integrity of intestinal epithelial cells
  • Paracellular permeability and tight junction regulation in gut health . . .
    We discuss the latest evidence that highlights tight junction components, structures and regulatory mechanisms, their impact on gut health and disease, and opportunities for therapeutic
  • SIRT1 stabilizes β-TrCP1 to inhibit Snail1 expression in maintaining . . .
    The effects of Nicotinamide mononucleotide (NMN) in DSS-induced mice colitis were investigated Correlations of the SIRT1-β-TrCP1-Snail1-Occludin Claudin-1 E-cadherin pathway with human IBD samples were analyzed
  • Intestinal Epithelial Tight Junction Barrier Regulation by Novel . . .
    We discuss the latest findings on intestinal tight junction barrier regulation by novel mechanisms including cytoskeleton and extracellular matrix proteins, signaling pathways, and cell survival mechanisms We also provide a perspective on the context-specific outcomes of the TJ barrier modulation





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