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  • Pathology Outlines - HCC - scirrhous type
    Scirrhous type of hepatocellular carcinoma is a subtype of hepatocellular carcinoma (HCC) designated by the WHO with abundant fibrous stroma separating nests and trabecula of tumor cells
  • Pathology Outlines - Hepatocellular carcinoma overview
    Glypican 3: cytoplasmic; high sensitivity in poorly differentiated and scirrhous hepatocellular carcinoma but low sensitivity in well differentiated hepatocellular carcinoma (nonneoplastic liver is negative) AFP: cytoplasmic; highly specific but low sensitivity; frequently negative in well differentiated hepatocellular carcinoma
  • Invasive breast cancer of no special type (NST)
    Most common type of invasive breast carcinoma (75 - 80%) and an invasive carcinoma with evidence of mammary epithelial origin either by morphology or immunohistochemistry
  • Pathology Outlines - WHO classification
    WHO classification of tumors of the liver and intrahepatic bile ducts Currently on 5th edition, published in 2019 Based on histologic appearance, not molecular characteristics
  • Pathology Outlines - Question Bank
    Which of the following is true regarding the scirrhous variant of hepatocellular carcinoma? Association with hypocalcemia has been described CK7 and CK19 are often negative It is associated with TSC1 TSC2 mutations There is often necrosis or hemorrhage
  • Pathology Outlines - Staging-hepatocellular carcinoma
    Hepatocellular carcinomas, including fibrolamellar carcinoma, are covered by the TNM staging system
  • Pathology Outlines - Micropapillary
    Breast malignant - Micropapillary carcinoma Micropapillary carcinoma is characterized by pseudopapillary, tubular and morular epithelial structures with inside out growth pattern (WHO Classification of Tumours Editorial Board: Breast Tumours, 5th Edition, 2019) Micropapillae are composed of cell clusters with inverted polarity floating in empty spaces and often separated by delicate strands of
  • Pathology Outlines - Solid papillary carcinoma
    Solid papillary carcinoma in situ is a form of ductal carcinoma in situ and is managed as such Surgical excision Radiation therapy in the setting of breast conserving
  • Pathology Outlines - Serous carcinoma
    Serous carcinoma is a high grade endometrial carcinoma with complex papillary, solid or glandular architecture and marked cytologic atypia, similar to tubo-ovarian high grade serous carcinoma
  • Pathology Outlines - Plexiform fibromyxoma
    Stomach - Plexiform fibromyxoma Benign mesenchymal neoplasm that predominantly arises in the gastric antrum and pyloric region Multinodular and plexiform architecture with arborizing vasculature at low power Cytologically bland spindle cells in myxoid or fibromyxoid stroma Rare or no mitotic figures; low proliferation index in most cases Metastases and recurrence following complete excision





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